Tissue Inhibitors of Metalloproteinases (TIMPs) are a family of proteins that regulate the activity of metalloproteinases, which are enzymes responsible for breaking down extracellular matrix components. By inhibiting these enzymes, TIMPs play a crucial role in maintaining tissue structure and function, as well as in processes like wound healing and tissue remodeling. There are four main types of TIMPs: TIMP-1, TIMP-2, TIMP-3, and TIMP-4. Each type has specific roles and is expressed in various tissues throughout the body. Dysregulation of TIMPs can lead to various diseases, including cancer and arthritis, highlighting their importance in health and disease management.