Sickle cell disease is a genetic blood disorder that affects the shape of red blood cells. Normally, these cells are round and flexible, allowing them to move easily through blood vessels. In sickle cell disease, the cells become rigid and shaped like a crescent or sickle, which can block blood flow and cause pain. This condition is inherited from parents who carry the sickle cell trait. People with sickle cell disease may experience symptoms such as anemia, fatigue, and frequent infections. Treatment options include pain management, blood transfusions, and medications to reduce complications associated with the disease.