Keratoderma is a skin condition characterized by thickened patches of skin, often found on the palms of the hands and soles of the feet. This thickening occurs due to an overproduction of keratin, a protein that helps protect the skin. Keratoderma can be inherited or acquired and may vary in severity and appearance. There are different types of keratoderma, including palmoplantar keratoderma, which specifically affects the palms and soles, and epidermolytic keratoderma, which is associated with blistering. Treatment options may include topical therapies, moisturizers, and in some cases, systemic medications to manage symptoms.