Palmoplantar keratoderma is a skin condition characterized by thickened skin on the palms of the hands and the soles of the feet. This thickening, or keratoderma, can cause discomfort and may lead to cracks or fissures in the skin. The condition can be inherited or acquired and varies in severity among individuals. There are different types of palmoplantar keratoderma, including hereditary palmoplantar keratoderma and acquired palmoplantar keratoderma. Treatment options may include topical therapies, such as moisturizers or keratolytics, to help manage symptoms and improve skin appearance. Regular care is essential to prevent complications.