Epidermolytic keratoderma is a rare genetic skin disorder characterized by thickened skin, particularly on the palms and soles. This condition results from mutations in the genes responsible for producing keratin, a protein that helps maintain skin structure and resilience. Individuals with this disorder often experience blistering and peeling, especially in response to friction or heat. The condition is usually inherited in an autosomal dominant pattern, meaning only one copy of the mutated gene is needed for a person to be affected. While there is no cure, management focuses on moisturizing the skin and preventing infections. Regular dermatological care can help improve quality of life for those affected.