WAGR syndrome is a rare genetic disorder that affects several body systems. It is characterized by a combination of symptoms, including Wilms tumor, aniridia (absence of the iris in the eye), genitourinary abnormalities, and intellectual disability. The condition is caused by a deletion of genetic material on chromosome 11, specifically in the 11p13 region. Individuals with WAGR syndrome may have an increased risk of developing certain cancers, particularly Wilms tumor, which is a type of kidney cancer. Early diagnosis and regular monitoring are essential for managing the symptoms and associated health risks. Treatment often involves a multidisciplinary approach, including medical care, educational support, and psychological assistance.