Transfusion-Related Hemosiderosis is a condition that occurs when excess iron accumulates in the body due to repeated blood transfusions. This is often seen in patients with chronic anemia or conditions like thalassemia and sickle cell disease, where regular transfusions are necessary for treatment. The body has limited ways to excrete iron, leading to potential damage to organs over time. The excess iron is stored in tissues as hemosiderin, which can affect the liver, heart, and pancreas, potentially causing serious complications. Monitoring iron levels and using treatments like iron chelation therapy can help manage this condition and reduce the risk of organ damage.