Primary Myelofibrosis is a rare blood disorder characterized by the abnormal production of blood cells in the bone marrow, leading to the formation of scar tissue. This condition disrupts normal blood cell production, resulting in anemia, fatigue, and an enlarged spleen. The exact cause of Primary Myelofibrosis is often unknown, but it is associated with mutations in genes such as JAK2, CALR, and MPL. Diagnosis typically involves blood tests, bone marrow biopsy, and imaging studies. Treatment options may include medications, blood transfusions, or stem cell transplantation, depending on the severity of the disease.