Chronic Myeloid Leukemia (CML) is a type of cancer that affects the blood and bone marrow. It occurs when the body produces too many abnormal white blood cells, which can crowd out healthy cells. CML is often linked to a genetic change called the Philadelphia chromosome, which results from a fusion of two genes. Symptoms of CML may include fatigue, weight loss, and an enlarged spleen. The disease typically progresses slowly and can be managed with targeted therapies, such as tyrosine kinase inhibitors, which help control the growth of cancer cells. Regular monitoring and treatment are essential for managing CML effectively.