PPAR-alpha (Peroxisome Proliferator-Activated Receptor Alpha) is a type of protein that plays a crucial role in regulating metabolism, particularly in the breakdown of fats. It is primarily found in the liver, heart, and muscle tissues, where it helps control the expression of genes involved in fatty acid oxidation and energy production. This receptor is activated by certain substances, including fatty acids and fibrates, which are medications used to lower cholesterol levels. When activated, PPAR-alpha promotes the use of fat as an energy source, thereby contributing to overall metabolic health and potentially reducing the risk of conditions like cardiovascular disease.