Hemoglobin H Disease is a type of alpha thalassemia, a genetic blood disorder that affects the production of hemoglobin, the protein in red blood cells that carries oxygen. Individuals with this condition have a reduced amount of normal hemoglobin and an excess of Hemoglobin H, which can lead to anemia, fatigue, and other health issues. This disease is caused by mutations in the HBA1 and HBA2 genes, which are responsible for producing the alpha globin chains of hemoglobin. Symptoms can vary in severity, and while some individuals may experience mild anemia, others may require medical treatment or blood transfusions to manage their condition.