The senescence-associated secretory phenotype (SASP) refers to a condition in which aging cells, known as senescent cells, secrete various pro-inflammatory factors, including cytokines, growth factors, and proteases. This secretion can influence surrounding cells and tissues, contributing to inflammation and tissue dysfunction. SASP is often observed in the context of aging and age-related diseases. SASP plays a significant role in the body's response to stress and damage, but its persistent activation can lead to detrimental effects. It is linked to various conditions, including cancer, diabetes, and cardiovascular diseases. Understanding SASP is crucial for developing potential therapies aimed at mitigating its harmful effects.