Hereditary palmoplantar keratoderma is a genetic skin condition characterized by thickened skin on the palms of the hands and soles of the feet. This condition can vary in severity and may cause discomfort or pain, affecting daily activities. It is often inherited in an autosomal dominant pattern, meaning only one copy of the mutated gene from a parent can cause the condition. The thickening of the skin occurs due to an overproduction of keratin, a protein that helps protect the skin. There are different types of hereditary palmoplantar keratoderma, including Vohwinkel syndrome and Epidermolytic palmoplantar keratoderma, each with unique features and associated symptoms. Treatment options focus on managing symptoms and may include topical therapies or other interventions.