Acquired palmoplantar keratoderma is a skin condition characterized by thickening of the skin on the palms of the hands and the soles of the feet. This condition can develop due to various factors, including genetic predisposition, environmental influences, or underlying health issues. It often leads to discomfort, pain, and difficulty in movement. The thickened skin may appear yellowish or brownish and can be associated with other symptoms, such as cracking or fissuring. Treatment options typically focus on managing symptoms and may include topical therapies, moisturizers, or, in some cases, systemic medications. Regular follow-up with a dermatologist is recommended for effective management.