A midfoot sprain is an injury that affects the ligaments in the middle part of the foot, often caused by twisting or rolling the ankle. This type of sprain can occur during sports activities, falls, or accidents. Symptoms typically include pain, swelling, and difficulty walking. Treatment for a midfoot sprain usually involves rest, ice, compression, and elevation, often referred to as the RICE method. In some cases, a brace or supportive footwear may be recommended to help stabilize the foot during recovery. Most people can return to normal activities within a few weeks, depending on the severity of the injury.