Epidermolytic palmoplantar keratoderma is a genetic skin condition characterized by thickened skin on the palms of the hands and soles of the feet. This condition results from mutations in the keratin genes, which are essential for maintaining skin structure and resilience. The thickening can lead to discomfort and may cause cracks or blisters. The condition is usually inherited in an autosomal dominant pattern, meaning only one copy of the mutated gene from a parent can cause the disorder. While there is no cure, treatments focus on managing symptoms and may include the use of moisturizers and keratolytic agents to soften the thickened skin.