Gluten-related disorders refer to a group of conditions triggered by the consumption of gluten, a protein found in wheat, barley, and rye. The most well-known of these disorders is celiac disease, an autoimmune condition where gluten damages the small intestine, leading to various health issues. Other conditions include non-celiac gluten sensitivity, which causes symptoms similar to celiac disease but without the intestinal damage, and wheat allergy, an allergic reaction to proteins in wheat. Diagnosis of gluten-related disorders typically involves a combination of medical history, blood tests, and sometimes a biopsy of the small intestine. Treatment primarily involves adhering to a strict gluten-free diet, which helps alleviate symptoms and prevent complications. Awareness and understanding of these disorders are essential for effective management and improved quality of life for those affected.