Artemisinin-based combination therapies (ACTs) are a type of treatment used to combat malaria, a serious disease caused by parasites transmitted through mosquito bites. ACTs combine artemisinin, a compound derived from the sweet wormwood plant, with another antimalarial drug. This combination enhances effectiveness and helps prevent the development of drug resistance. ACTs are recommended by the World Health Organization (WHO) as the first-line treatment for uncomplicated malaria caused by Plasmodium falciparum, the most deadly malaria parasite. By using two different mechanisms of action, ACTs improve treatment outcomes and reduce the chances of the malaria parasite surviving the treatment.