Princess Sophie Charlotte was born on March 19, 1744, in Berlin, Prussia. She was the daughter of King Frederick II of Prussia and Elisabeth Christine of Brunswick-Wolfenbüttel. In 1763, she married Duke Charles of Mecklenburg-Strelitz, becoming the Duchess of Mecklenburg-Strelitz.
Sophie Charlotte was known for her intelligence and cultural contributions. She played a significant role in the arts and sciences during her time, hosting many prominent intellectuals at her court. Her legacy includes the establishment of the Charlotte Palace in Berlin, which became a center for cultural activities in the region.