PI(3,4,5)P3, or phosphatidylinositol (3,4,5)-trisphosphate, is a lipid molecule found in cell membranes. It plays a crucial role in cellular signaling, particularly in the pathways that regulate cell growth, survival, and metabolism. PI(3,4,5)P3 is produced by the action of phosphoinositide 3-kinase (PI3K) on phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). Once generated, PI(3,4,5)P3 serves as a docking site for various proteins with specific domains, such as AKT, which is involved in promoting cell survival and growth. The presence of PI(3,4,5)P3 in the membrane helps activate signaling cascades that influence numerous cellular functions, making it a key player in