Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a phospholipid found in the inner layer of cell membranes. It plays a crucial role in cellular signaling and acts as a precursor for important signaling molecules. PI(4,5)P2 is involved in various cellular processes, including the regulation of ion channels and the activation of certain proteins. Additionally, PI(4,5)P2 is essential for the formation of clathrin-coated vesicles, which are important for transporting materials within cells. It also participates in the phosphoinositide signaling pathway, influencing processes such as cell growth, survival, and movement.