Phosphoinositide 3-Kinase (PI3K) is an enzyme that plays a crucial role in cellular functions, including growth, proliferation, and survival. It is involved in signaling pathways that respond to various stimuli, such as hormones and growth factors. By converting a specific lipid in the cell membrane, PI3K generates signaling molecules that activate other proteins, leading to various cellular responses. There are different classes of PI3K, each with distinct functions and regulatory mechanisms. Class I PI3Ks are primarily activated by receptor tyrosine kinases, while Class II and Class III PI3Ks have different roles in cellular processes. Dysregulation of PI3K signaling is associated with several diseases, including cancer and metabolic disorders.