Muckle-Wells Syndrome is a rare genetic condition that primarily affects the immune system. It is characterized by recurrent episodes of fever, rash, and joint pain, which are caused by inflammation. This syndrome is caused by mutations in the NLRP3 gene, which plays a crucial role in regulating the body's inflammatory response. Individuals with Muckle-Wells Syndrome may also experience hearing loss and can develop a condition called amyloidosis, where abnormal protein deposits accumulate in organs. Early diagnosis and treatment are important to manage symptoms and prevent complications. Treatment often includes medications to reduce inflammation and control symptoms.