Large motor neurons are specialized nerve cells that transmit signals from the brain and spinal cord to muscles, enabling movement. They are characterized by their large cell bodies and long axons, which can extend over considerable distances in the body. These neurons play a crucial role in controlling voluntary movements, such as walking and grasping. These neurons are primarily found in the spinal cord and the brainstem. They connect to muscle fibers at junctions called neuromuscular junctions, where they release neurotransmitters to stimulate muscle contraction. Damage to large motor neurons can lead to conditions like amyotrophic lateral sclerosis (ALS), resulting in muscle weakness and atrophy.