Kavalactones are natural compounds found in the root of the kava plant, which is native to the South Pacific. These compounds are primarily responsible for the calming and relaxing effects associated with kava consumption. Kavalactones interact with neurotransmitter systems in the brain, particularly affecting GABA receptors, which can help reduce anxiety and promote a sense of well-being. There are several types of kavalactones, each contributing to the overall effects of kava. Common kavalactones include kavain, dihydrokavain, and yangonin. The concentration and combination of these kavalactones can vary between different kava strains, influencing their potency and effects on mood and relaxation.