Infectious Salmon Anemia Virus (ISAV) is a viral pathogen that primarily affects farmed Atlantic salmon. It is responsible for a serious disease known as Infectious Salmon Anemia (ISA), which can lead to significant economic losses in the aquaculture industry. The virus is highly contagious and can spread rapidly among fish populations, particularly in crowded farming conditions. ISAV is an enveloped RNA virus belonging to the Orthomyxoviridae family. Infected fish may show symptoms such as lethargy, anemia, and hemorrhaging, particularly around the gills and skin. Effective management strategies, including biosecurity measures and vaccination, are essential to control the spread of this virus in aquaculture settings.