Orthomyxoviridae is a family of viruses known for causing influenza, commonly referred to as the flu. These viruses are characterized by their segmented RNA genomes and are enveloped, meaning they have a lipid membrane surrounding them. The family includes several important strains, such as Influenza A, Influenza B, and Influenza C, each of which can infect humans and animals. The Orthomyxoviridae viruses are known for their ability to mutate and reassort, leading to new strains that can evade the immune system. This is why seasonal flu vaccines are updated annually to provide protection against the most prevalent strains. Understanding these viruses is crucial for public health and disease prevention.