Hyperimmunoglobulinemia D Syndrome (HIDS) is a rare genetic disorder characterized by recurrent episodes of fever and elevated levels of immunoglobulin D (IgD) in the blood. It is caused by mutations in the MVK gene, which plays a role in the body's immune response. Symptoms often include abdominal pain, joint pain, and skin rashes, typically occurring in childhood. The condition is classified as a type of autoinflammatory disease, meaning it results from an abnormal immune response rather than an infection. Management focuses on alleviating symptoms, and some patients may benefit from medications like colchicine or nonsteroidal anti-inflammatory drugs (NSAIDs) to reduce inflammation and pain.