The House of Lorraine is a noble family that originated in the region of Lorraine, located in present-day northeastern France. It became prominent in the medieval period and played a significant role in European politics, particularly during the Hundred Years' War and the Italian Wars. The family produced several notable rulers and military leaders. One of the most famous branches of the House of Lorraine is the House of Guise, which was influential in French politics during the 16th century. The family also includes Francis I of Lorraine, who became Holy Roman Emperor. The House of Lorraine's legacy continues to be felt in European history.