The House of Guise was a prominent noble family in France during the 16th and 17th centuries. They played a significant role in the French Wars of Religion, aligning with the Catholic League against the Protestant Huguenots. The family was known for its political power and influence, particularly through figures like Henry I, Duke of Guise. The Guise family originated from the region of Lorraine and was closely related to the royal family. Their rivalry with the House of Bourbon and involvement in various political intrigues contributed to the instability of France during this period. The family's legacy is marked by their ambition and the conflicts they instigated.