The House of Guise was a prominent noble family in France during the 16th and 17th centuries. They played a significant role in the French Wars of Religion, which were conflicts between Catholics and Protestants. The family was known for its strong Catholic stance and ambition for power, often clashing with the House of Bourbon. Founded by Claude de Guise, the house produced several influential figures, including Henry I, Duke of Guise, who was a key player in the political and religious turmoil of the time. The family's influence waned after the assassination of Henry III in 1588, leading to their decline in power.