Hedgehog ligands are signaling molecules that play a crucial role in the Hedgehog signaling pathway, which is important for cell growth, differentiation, and tissue patterning during embryonic development. The primary hedgehog ligands include Sonic Hedgehog (Shh), Indian Hedgehog (Ihh), and Desert Hedgehog (Dhh). These ligands bind to specific receptors on target cells, initiating a cascade of cellular responses. The Hedgehog signaling pathway is vital for various biological processes, including the development of the nervous system and limb formation. Abnormalities in this pathway can lead to developmental disorders and contribute to the progression of certain cancers, making hedgehog ligands a significant focus in medical research.