Fibrates are a class of medications primarily used to lower triglycerides and increase high-density lipoprotein (HDL) cholesterol levels in the blood. They work by activating a specific receptor in the body called peroxisome proliferator-activated receptor alpha (PPAR-alpha), which helps to break down fats and improve lipid profiles. Common fibrates include fenofibrate and gemfibrozil. These medications are often prescribed for individuals with high cholesterol or those at risk of cardiovascular disease. While effective, fibrates can have side effects and may interact with other medications, so it's important for patients to consult their healthcare provider before starting treatment.