Peroxisome proliferator-activated receptor alpha (PPAR-alpha) is a type of protein that plays a crucial role in regulating lipid metabolism and energy homeostasis in the body. It is primarily found in the liver, heart, and muscle tissues, where it helps control the breakdown of fatty acids and the production of energy. PPAR-alpha is activated by certain fatty acids and drugs, leading to changes in gene expression that promote the oxidation of fats. This process is important for maintaining healthy levels of cholesterol and triglycerides, making PPAR-alpha a target for treatments related to metabolic disorders and cardiovascular diseases.