Eastern equine encephalitis (EEE) is a rare but serious viral infection that affects the brain. It is caused by the Eastern equine encephalitis virus, which is primarily transmitted to humans through the bite of infected mosquitoes. Symptoms can include fever, headache, and confusion, and in severe cases, it can lead to seizures or coma. EEE is most common in certain regions of the United States, particularly in the Northeast and Southeast. While there is no specific treatment for the infection, supportive care can help manage symptoms. Vaccines are available for horses, which can help reduce the risk of transmission to humans.