Cholesterol-lowering drugs, also known as lipid-lowering medications, are used to reduce levels of cholesterol in the blood. High cholesterol can lead to heart disease and other cardiovascular issues. The most common types of these drugs are statins, which work by blocking a substance your body needs to make cholesterol. Other types of cholesterol-lowering medications include bile acid sequestrants, niacin, and PCSK9 inhibitors. These drugs can help lower low-density lipoprotein (LDL) cholesterol, often referred to as "bad" cholesterol, and may also raise high-density lipoprotein (HDL) cholesterol, known as "good" cholesterol.