PCSK9 inhibitors are a class of medications designed to lower cholesterol levels in the blood. They work by blocking a protein called PCSK9, which normally reduces the liver's ability to remove LDL cholesterol (often referred to as "bad" cholesterol) from the bloodstream. By inhibiting this protein, these drugs help increase the liver's capacity to clear LDL cholesterol, leading to lower levels in the body. These medications are typically prescribed for individuals who have high cholesterol that does not respond well to standard treatments, such as statins. PCSK9 inhibitors can significantly reduce the risk of heart disease and related complications by effectively managing cholesterol levels.