Caroline of Hesse-Rheinfels was a German princess born on December 24, 1746. She was the daughter of Landgrave William of Hesse-Rheinfels and Countess Caroline of Nassau-Usingen. Caroline married Duke Charles of Mecklenburg-Strelitz in 1763, becoming the Duchess of Mecklenburg-Strelitz. Throughout her life, Caroline was known for her cultural contributions and support of the arts. She played a significant role in the court life of Mecklenburg-Strelitz and was involved in various charitable activities. Caroline passed away on June 28, 1810, leaving a legacy of cultural influence in her region.