ADAMTS5
ADAMTS5 is a protein that belongs to the ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) family. It plays a crucial role in the breakdown of extracellular matrix components, particularly aggrecan, which is important for maintaining the structure and function of cartilage. This protein is primarily expressed in tissues such as cartilage and is involved in processes like tissue remodeling and repair.
Research has shown that ADAMTS5 is significant in various conditions, including osteoarthritis and intervertebral disc degeneration. Its activity can influence the progression of these diseases by affecting the balance between cartilage formation and degradation. Understanding ADAMTS5 may lead to potential therapeutic targets for treating joint and cartilage-related disorders.