ADAMTS4 is a protein that belongs to the ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) family. It plays a crucial role in the breakdown of extracellular matrix components, particularly aggrecan, which is important for maintaining the structure and function of cartilage. This protein is primarily expressed in cartilage and is involved in various biological processes, including tissue remodeling and repair. Abnormal activity of ADAMTS4 has been linked to conditions such as osteoarthritis and other joint disorders, highlighting its significance in maintaining joint health.