ADAMTS-2 is a protein that belongs to the ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) family. It plays a crucial role in the processing of extracellular matrix components, particularly in the degradation of collagen and proteoglycans. This function is important for maintaining the structural integrity of tissues. Mutations in the ADAMTS-2 gene can lead to various connective tissue disorders, such as Ehlers-Danlos syndrome. This condition is characterized by hyper-flexible joints and skin that is easily bruised or stretched. Understanding ADAMTS-2 is essential for developing potential treatments for these genetic disorders.