ADAMTS-1 is a protein that belongs to the ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) family. It plays a crucial role in the breakdown of extracellular matrix components, particularly aggrecan, which is important for maintaining the structure of cartilage. This protein is involved in various biological processes, including tissue remodeling and repair. Research has shown that ADAMTS-1 is implicated in several conditions, such as osteoarthritis and cancer. Its activity can influence inflammation and tumor progression, making it a potential target for therapeutic interventions. Understanding the function of ADAMTS-1 may lead to new strategies for treating these diseases.