3-hydroxy-3-methylglutaryl coenzyme A, often abbreviated as HMG-CoA, is a crucial compound in the body's metabolic processes. It plays a significant role in the synthesis of cholesterol and other important biomolecules. HMG-CoA is produced in the liver and is a key intermediate in the mevalonate pathway, which is essential for lipid metabolism. In addition to its role in cholesterol production, HMG-CoA is also the target of certain medications known as statins. These drugs help lower cholesterol levels in the blood by inhibiting the enzyme that converts HMG-CoA to mevalonate, thereby reducing the risk of cardiovascular diseases.