A syndesmosis sprain is an injury to the syndesmosis, which is the fibrous joint connecting the two bones of the lower leg, the tibia and fibula. This type of sprain often occurs during activities that involve twisting or sudden changes in direction, such as in sports like football or basketball. Symptoms of a syndesmosis sprain include pain, swelling, and difficulty walking. Treatment typically involves rest, ice, compression, and elevation (RICE), along with physical therapy to restore strength and mobility. In severe cases, surgery may be required to stabilize the joint.