A sickle cell crisis occurs when the red blood cells, which are normally round, become rigid and shaped like a crescent or sickle. This change can block blood flow in small blood vessels, leading to pain and potential damage to organs. The crises can be triggered by factors such as dehydration, extreme temperatures, or infections. During a crisis, individuals may experience severe pain, often in the chest, abdomen, or joints. Treatment typically involves pain relief, hydration, and sometimes blood transfusions. People with sickle cell disease are at risk for recurrent crises throughout their lives, making management and prevention essential.