Neutral ceramidase is an enzyme that plays a crucial role in lipid metabolism by breaking down ceramides into sphingosine and free fatty acids. This process is important for maintaining cellular health and regulating various biological functions, including cell signaling and inflammation. The activity of neutral ceramidase is particularly significant in the skin, where it helps to maintain the skin barrier and hydration. Dysregulation of this enzyme has been linked to various skin disorders and other health issues, highlighting its importance in both dermatology and overall metabolic health.