Ceramidases are enzymes that play a crucial role in lipid metabolism by breaking down ceramides, a type of fat molecule found in cell membranes. They convert ceramides into sphingosine and fatty acids, which are important for various cellular functions, including signaling and maintaining cell structure. These enzymes are categorized into different types based on their optimal pH levels and cellular locations. Dysregulation of ceramidase activity can lead to various health issues, including neurodegenerative diseases and skin disorders. Understanding ceramidases is essential for developing potential therapies targeting these conditions.