Metalloproteinases are a group of enzymes that play a crucial role in breaking down proteins in the body. They require metal ions, such as zinc or calcium, to function effectively. These enzymes are involved in various biological processes, including tissue remodeling, wound healing, and the development of certain diseases. There are different types of metalloproteinases, including matrix metalloproteinases (MMPs) and adams (a disintegrin and metalloproteinase). MMPs are particularly important for degrading components of the extracellular matrix, which provides structural support to tissues. Dysregulation of metalloproteinases can lead to conditions like arthritis and cancer.