Metalloproteinases are a group of enzymes that play a crucial role in breaking down proteins in the extracellular matrix, which is the network of proteins and other molecules that provide structural support to cells. They require metal ions, usually zinc or calcium, to function effectively. These enzymes are involved in various physiological processes, including tissue remodeling, wound healing, and embryonic development. In addition to their normal functions, metalloproteinases can be implicated in various diseases, such as arthritis, cancer, and cardiovascular disorders. Their activity is tightly regulated, as excessive or uncontrolled metalloproteinase activity can lead to tissue damage and contribute to disease progression.