Metalloproteases are a type of enzyme that play a crucial role in breaking down proteins. They require metal ions, such as zinc or calcium, to function effectively. These enzymes are involved in various biological processes, including tissue remodeling, cell signaling, and immune responses. These enzymes are found in many organisms, from bacteria to humans. In humans, metalloproteases are important for wound healing and the development of certain diseases, such as cancer and arthritis. Their activity is tightly regulated, as imbalances can lead to pathological conditions.